ABSTRACT
OBJECTIVE: To further study the chemical constituents of Zygophyllum fabago L. by classic phytochemical methods. METHODS: The compounds were isolated from the ethyl accetate extract by silica column chromatography, Sephadex LH-20 column chromatography and RP-18 reverse-phase column chromatography. The structures were characterized by spectroscopy (1H-NMR and 13C-NMR) and comparison with the data of literatures. RESULTS: Thirteen compounds were isolated from the ethyl acetate extract,and ten compounds were phenolic constituents. The compounds were identified as erythro-3, 3′-dimethoxy-4, 8′-oxyneoligna-9, 4′, 7′, 9′-tetraol-7(8)-ene (1), threo-3, 3′-dimethoxy-4, 8′-oxyneoligna-9, 4′, 7′, 9′-tetraol-7(8)-ene (2), erythro-1, 2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1, 3-diol (3), threo-1, 2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1, 3-diol (4), maninsigin B (5), scopoletin (6), 2-hydroxyl-1- (7), vanillin (8), paeonol (9), 4-(4′-O-D-glucopyranosyl-3′-methoxyphenyl)-2-butanone (10), actractylodin (11), acetylatractylodinol (12), and squalene (13). CONCLUSION: Compounds 1-13 are obtained from this plant for the first time.